This project carried out in Bioferma Murcia S. A. started from a process partially deployed at pilot scale, with yields under 50% of the claimed in the description of the technology acquired. In one year of work at pilot scale, the conditions foreseen for the industrial scale, including raw materials, seed phases and fermentation process, were reproduced, improving during the second year the production at pilot scale to the design values.
The design of the industrial plant equipped with six 125 m3 fermenters, was reviewed for sterile process requirements almost in parallel to the construction of the plant, with very little room for modifications. The start-up of the fermentation area was carried out very successfully, reaching design production yields in two months. After a year of operation, the fermentation plant was yielding 15% over the design productivity.